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Key role for Bak activation and Bak-Bax interaction in the apoptotic response to vinblastine
Microtubule inhibitors such as vinblastine cause mitotic arrest and subsequent apoptosis through the intrinsic mitochondrial pathway. However, while Bcl-2 family proteins have been implicated as distal mediators, their precise role is largely unknown. In this study we investigated the role of Bak in...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2008
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3276366/ https://ncbi.nlm.nih.gov/pubmed/18645031 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-07-2299 |
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