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Parkin inhibits BAK and BAX apoptotic function by distinct mechanisms during mitophagy
The E3 ubiquitin ligase Parkin is a key effector of the removal of damaged mitochondria by mitophagy. Parkin determines cell fate in response to mitochondrial damage, with its loss promoting early onset Parkinson's disease and potentially also cancer progression. Controlling a cell's apopt...
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| 出版年: | EMBO J |
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| 主要な著者: | , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
John Wiley and Sons Inc.
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6331729/ https://ncbi.nlm.nih.gov/pubmed/30573668 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201899916 |
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