Coupled single-cell CRISPR screening and epigenomic profiling reveals causal gene regulatory networks

Here we present Perturb-ATAC, a method which combines multiplexed CRISPR interference or knockout with genome-wide chromatin accessibility profiling in single cells, based on the simultaneous detection of CRISPR guide RNAs and open chromatin sites by assay of transposase-accessible chromatin with se...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Rubin, Adam J., Parker, Kevin R., Satpathy, Ansuman T., Qi, Yanyan, Wu, Beijing, Ong, Alvin J., Mumbach, Maxwell R., Ji, Andrew L., Kim, Daniel S., Cho, Seung Woo, Zarnegar, Brian J., Greenleaf, William J., Chang, Howard Y., Khavari, Paul A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6329648/
https://ncbi.nlm.nih.gov/pubmed/30580963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.11.022
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