Coupled single-cell CRISPR screening and epigenomic profiling reveals causal gene regulatory networks

Here we present Perturb-ATAC, a method which combines multiplexed CRISPR interference or knockout with genome-wide chromatin accessibility profiling in single cells, based on the simultaneous detection of CRISPR guide RNAs and open chromatin sites by assay of transposase-accessible chromatin with se...

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Publicado en:Cell
Main Authors: Rubin, Adam J., Parker, Kevin R., Satpathy, Ansuman T., Qi, Yanyan, Wu, Beijing, Ong, Alvin J., Mumbach, Maxwell R., Ji, Andrew L., Kim, Daniel S., Cho, Seung Woo, Zarnegar, Brian J., Greenleaf, William J., Chang, Howard Y., Khavari, Paul A.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6329648/
https://ncbi.nlm.nih.gov/pubmed/30580963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.11.022
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