Single-cell epigenomic variability reveals functional cancer heterogeneity

BACKGROUND: Cell-to-cell heterogeneity is a major driver of cancer evolution, progression, and emergence of drug resistance. Epigenomic variation at the single-cell level can rapidly create cancer heterogeneity but is difficult to detect and assess functionally. RESULTS: We develop a strategy to bri...

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Detalles Bibliográficos
Publicado en:Genome Biol
Autores principales: Litzenburger, Ulrike M., Buenrostro, Jason D., Wu, Beijing, Shen, Ying, Sheffield, Nathan C., Kathiria, Arwa, Greenleaf, William J., Chang, Howard Y.
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5259890/
https://ncbi.nlm.nih.gov/pubmed/28118844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-016-1133-7
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