Coupled single-cell CRISPR screening and epigenomic profiling reveals causal gene regulatory networks

Here we present Perturb-ATAC, a method which combines multiplexed CRISPR interference or knockout with genome-wide chromatin accessibility profiling in single cells, based on the simultaneous detection of CRISPR guide RNAs and open chromatin sites by assay of transposase-accessible chromatin with se...

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Bibliographic Details
Published in:Cell
Main Authors: Rubin, Adam J., Parker, Kevin R., Satpathy, Ansuman T., Qi, Yanyan, Wu, Beijing, Ong, Alvin J., Mumbach, Maxwell R., Ji, Andrew L., Kim, Daniel S., Cho, Seung Woo, Zarnegar, Brian J., Greenleaf, William J., Chang, Howard Y., Khavari, Paul A.
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6329648/
https://ncbi.nlm.nih.gov/pubmed/30580963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.11.022
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