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Transthyretin Aggregation Pathway toward the Formation of Distinct Cytotoxic Oligomers

Characterization of small oligomers formed at an early stage of amyloid formation is critical to understanding molecular mechanism of pathogenic aggregation process. Here we identified and characterized cytotoxic oligomeric intermediates populated during transthyretin (TTR) aggregation process. Unde...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Dasari, Anvesh K. R., Hughes, Robert M., Wi, Sungsool, Hung, Ivan, Gan, Zhehong, Kelly, Jeffrey W., Lim, Kwang Hun
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6328637/
https://ncbi.nlm.nih.gov/pubmed/30631096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-37230-1
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