Tamoxifen mechanically reprograms the tumor microenvironment via HIF‐1A and reduces cancer cell survival

The tumor microenvironment is fundamental to cancer progression, and the influence of its mechanical properties is increasingly being appreciated. Tamoxifen has been used for many years to treat estrogen‐positive breast cancer. Here we report that tamoxifen regulates the level and activity of collag...

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Detalhes bibliográficos
Publicado no:EMBO Rep
Main Authors: Cortes, Ernesto, Lachowski, Dariusz, Robinson, Benjamin, Sarper, Muge, Teppo, Jaakko S, Thorpe, Stephen D, Lieberthal, Tyler J, Iwamoto, Kazunari, Lee, David A, Okada‐Hatakeyama, Mariko, Varjosalo, Markku T, del Río Hernández, Armando E
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6322388/
https://ncbi.nlm.nih.gov/pubmed/30538116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201846557
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