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Multifunctional Donepezil Analogues as Cholinesterase and BACE1 Inhibitors
A series of 22 donepezil analogues were synthesized through alkylation/benzylation and compared to donepezil and its 6-O-desmethyl adduct. All the compounds were found to be potent inhibitors of both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), two enzymes responsible for the hydrol...
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| Publicado no: | Molecules |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6321525/ https://ncbi.nlm.nih.gov/pubmed/30544832 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23123252 |
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