Investigating the promiscuity of the chloramphenicol nitroreductase from Haemophilus influenzae towards the reduction of 4-nitrobenzene derivatives

Chloramphenicol nitroreductase (CNR), a drug-modifying enzyme from Haemophilus influenzae, has been shown to be responsible for the conversion of the nitro group into an amine in the antibiotic chloramphenicol (CAM). Since CAM structurally bears a 4-nitrobenzene moiety, we explored the substrate pro...

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Bibliografische gegevens
Gepubliceerd in:Bioorg Med Chem Lett
Hoofdauteurs: Green, Keith D., Fosso, Marina Y., Mayhoub, Abdelrahman S., Garneau-Tsodikova, Sylvie
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6431269/
https://ncbi.nlm.nih.gov/pubmed/30826292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.02.025
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