Cysteinyl leukotriene 2 receptor promotes endothelial permeability, tumor angiogenesis, and metastasis

Cysteinyl leukotrienes (cys-LTs) are proinflammatory mediators that enhance vascular permeability through distinct receptors (CysLTRs). We found that CysLT(2)R regulates angiogenesis in isolated mouse endothelial cells (ECs) and in Matrigel implants in WT mice and enhances EC contraction and permeab...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Duah, Ernest, Teegala, Lakshminarayan Reddy, Kondeti, Vinay, Adapala, Ravi K., Keshamouni, Venkateshwar G., Kanaoka, Yoshihide, Austen, K. Frank, Thodeti, Charles K., Paruchuri, Sailaja
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6320507/
https://ncbi.nlm.nih.gov/pubmed/30559191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1817325115
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