Cysteinyl leukotrienes regulate endothelial cell inflammatory and proliferative signals through CysLT(2) and CysLT(1) receptors

Cysteinyl leukotrienes (cys-LTs), LTC(4), LTD(4), LTE(4) are potent inflammatory lipid mediators that act through two distinct G-protein-coupled receptors, CysLT(1)R and CysLT(2)R. Although cys-LTs are shown to induce vascular leakage and atherosclerosis, the molecular mechanism by which cys-LTs mod...

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Main Authors: Duah, Ernest, Adapala, Ravi K., Al-Azzam, Nosayba, Kondeti, Vinay, Gombedza, Farai, Thodeti, Charles K., Paruchuri, Sailaja
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3834363/
https://ncbi.nlm.nih.gov/pubmed/24253666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep03274
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