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CysLT(2) receptors interact with CysLT(1) receptors and down-modulate cysteinyl leukotriene–dependent mitogenic responses of mast cells
Cysteinyl leukotrienes (cys-LTs) induce inflammation through 2 G protein–coupled receptors (GPCRs), CysLT(1) and CysLT(2), which are coexpressed by most myeloid cells. Cys-LTs induce proliferation of mast cells (MCs), transactivate c-Kit, and phosphorylate extracellular signal-regulated kinase (ERK)...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society of Hematology
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2200919/ https://ncbi.nlm.nih.gov/pubmed/17693579 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-07-100453 |
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