CysLT(2) receptors interact with CysLT(1) receptors and down-modulate cysteinyl leukotriene–dependent mitogenic responses of mast cells

Cysteinyl leukotrienes (cys-LTs) induce inflammation through 2 G protein–coupled receptors (GPCRs), CysLT(1) and CysLT(2), which are coexpressed by most myeloid cells. Cys-LTs induce proliferation of mast cells (MCs), transactivate c-Kit, and phosphorylate extracellular signal-regulated kinase (ERK)...

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Auteurs principaux: Jiang, Yongfeng, Borrelli, Laura A., Kanaoka, Yoshihide, Bacskai, Brian J., Boyce, Joshua A.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2007
Sujets:
Immunobiology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2200919/
https://ncbi.nlm.nih.gov/pubmed/17693579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-07-100453
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