Myeloid-Derived Suppressor Cells Produce IL-10 to Elicit DNMT3b-Dependent IRF8 Silencing to Promote Colitis-Associated Colon Tumorigenesis

IL-10 functions as a suppressor of colitis and colitis-associated colon cancer, but it is also a risk locus associated with ulcerative colitis. The mechanism underlying the contrasting roles of IL-10 in inflammation and colon cancer is unknown. We report here that inflammation induces the accumulati...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Ibrahim, Mohammed L., Klement, John D., Lu, Chunwan, Redd, Priscilla S., Xiao, Wei, Yang, Dafeng, Browning, Darren D., Savage, Natasha M., Buckhaults, Phillip J., Morse, Herbert C., Liu, Kebin
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6319669/
https://ncbi.nlm.nih.gov/pubmed/30540937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.11.050
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