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Histone Tail Sequences Balance Their Role in Genetic Regulation and the Need to Protect DNA Against Destruction in Nucleosome Core Particles Containing Abasic Sites
Abasic sites (AP) are produced 10,000 times in a single cell per day. Strand cleavage at AP is accelerated ~100-fold within a nucleosome core particle (NCP) compared to free DNA. The lysine (Lys) rich N-terminal tails of histone proteins catalyze single strand break formation via a mechanism utilize...
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| Published in: | Chembiochem |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2018
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6317330/ https://ncbi.nlm.nih.gov/pubmed/30307690 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201800559 |
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