Common binding sites for cholesterol and neurosteroids on a pentameric ligand-gated ion channel

Cholesterol is an essential component of cell membranes, and is required for mammalian pentameric ligand-gated ion channel (pLGIC) function. Computational studies suggest direct interactions between cholesterol and pLGIC’s but experimental evidence identifying specific binding sites is limited. In t...

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Publicat a:Biochim Biophys Acta Mol Cell Biol Lipids
Autors principals: Budelier, Melissa M., Cheng, Wayland W. L., Chen, Zi-Wei, Bracamontes, John R., Sugasawa, Yusuke, Kathiresan, Krishnan, Mydock-McGrane, Laurel, Covey, Douglas F., Evers, Alex S.
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6311151/
https://ncbi.nlm.nih.gov/pubmed/30471426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2018.11.005
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