Multiple neurosteroid and cholesterol binding sites in voltage-dependent anion channel-1 determined by photo-affinity labeling

Voltage-dependent anion channel-1 (VDAC1) is a mitochondrial porin that is implicated in cellular metabolism and apoptosis, and modulated by numerous small molecules including lipids. VDAC1 binds sterols, including cholesterol and neurosteroids such as allopregnanolone. Biochemical and computational...

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Udgivet i:Biochim Biophys Acta Mol Cell Biol Lipids
Main Authors: Cheng, Wayland W.L., Budelier, Melissa M., Sugasawa, Yusuke, Bergdoll, Lucie, Queralt-Martín, María, Rosencrans, William, Rostovtseva, Tatiana K., Chen, Zi-Wei, Abramson, Jeff, Krishnan, Kathiresan, Covey, Douglas F., Whitelegge, Julian P., Evers, Alex S.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6681461/
https://ncbi.nlm.nih.gov/pubmed/31176038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2019.06.004
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