Photoaffinity labeling with cholesterol analogues precisely maps a cholesterol-binding site in voltage-dependent anion channel-1

Voltage-dependent anion channel-1 (VDAC1) is a highly regulated β-barrel membrane protein that mediates transport of ions and metabolites between the mitochondria and cytosol of the cell. VDAC1 co-purifies with cholesterol and is functionally regulated by cholesterol, among other endogenous lipids....

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Budelier, Melissa M., Cheng, Wayland W. L., Bergdoll, Lucie, Chen, Zi-Wei, Janetka, James W., Abramson, Jeff, Krishnan, Kathiresan, Mydock-McGrane, Laurel, Covey, Douglas F., Whitelegge, Julian P., Evers, Alex S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2017
Schlagworte:
Molecular Biophysics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5454110/
https://ncbi.nlm.nih.gov/pubmed/28396346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.773069
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