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Perspectives on In Vitro to In Vivo Extrapolations

Quantitative in vitro to in vivo extrapolation (QIVIVE) is broadly considered a prerequisite bridge from in vitro findings to a dose paradigm. Quality and relevance of cell systems are the first prerequisite for QIVIVE. Information-rich and mechanistic endpoints (biomarkers) improve extrapolations,...

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Bibliografske podrobnosti
izdano v:Appl In Vitro Toxicol
Glavni avtor: Hartung, Thomas
Format: Artigo
Jezik:Inglês
Izdano: Mary Ann Liebert, Inc., publishers 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6309130/
https://ncbi.nlm.nih.gov/pubmed/31890748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/aivt.2016.0026
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