Using the concordance of in vitro and in vivo data to evaluate extrapolation assumptions

Linking in vitro bioactivity and in vivo toxicity on a dose basis enables the use of high-throughput in vitro assays as an alternative to traditional animal studies. In this study, we evaluated assumptions in the use of a high-throughput, physiologically based toxicokinetic (PBTK) model to relate in...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Honda, Gregory S., Pearce, Robert G., Pham, Ly L., Setzer, R. W., Wetmore, Barbara A., Sipes, Nisha S., Gilbert, Jon, Franz, Briana, Thomas, Russell S., Wambaugh, John F.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6538186/
https://ncbi.nlm.nih.gov/pubmed/31136631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0217564
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