Evaluating In Vitro-In Vivo Extrapolation of Toxicokinetics

Prioritizing the risk posed by thousands of chemicals potentially present in the environment requires exposure, toxicity, and toxicokinetic (TK) data, which are often unavailable. Relatively high throughput, in vitro TK (HTTK) assays and in vitro-to-in vivo extrapolation (IVIVE) methods have been de...

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Detalhes bibliográficos
Publicado no:Toxicol Sci
Main Authors: Wambaugh, John F, Hughes, Michael F, Ring, Caroline L, MacMillan, Denise K, Ford, Jermaine, Fennell, Timothy R, Black, Sherry R, Snyder, Rodney W, Sipes, Nisha S, Wetmore, Barbara A, Westerhout, Joost, Setzer, R Woodrow, Pearce, Robert G, Simmons, Jane Ellen, Thomas, Russell S
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Ivive and Toxicokinetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5920326/
https://ncbi.nlm.nih.gov/pubmed/29385628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfy020
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