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Type 2 deiodinase polymorphism causes ER stress and hypothyroidism in the brain
Levothyroxine (LT4) is a form of thyroid hormone used to treat hypothyroidism. In the brain, T4 is converted to the active form T3 by type 2 deiodinase (D2). Thus, it is intriguing that carriers of the Thr92Ala polymorphism in the D2 gene (DIO2) exhibit clinical improvement when liothyronine (LT3) i...
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| Publicado no: | J Clin Invest |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6307951/ https://ncbi.nlm.nih.gov/pubmed/30352046 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI123176 |
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