Type 2 Deiodinase Disruption in Astrocytes Results in Anxiety-Depressive-Like Behavior in Male Mice

Millions of levothyroxine-treated hypothyroid patients complain of impaired cognition despite normal TSH serum levels. This could reflect abnormalities in the type 2 deiodinase (D2)-mediated T(4)-to-T(3) conversion, given their much greater dependence on the D2 pathway for T(3) production. T(3) norm...

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Dettagli Bibliografici
Pubblicato in:Endocrinology
Autori principali: Bocco, Barbara M. L. C., Werneck-de-Castro, João Pedro, Oliveira, Kelen C., Fernandes, Gustavo W., Fonseca, Tatiana L., Nascimento, Bruna P. P., McAninch, Elizabeth A., Ricci, Esther, Kvárta-Papp, Zsuzsanna, Fekete, Csaba, Bernardi, Maria Martha, Gereben, Balázs, Bianco, Antonio C., Ribeiro, Miriam O.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Endocrine Society 2016
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5007895/
https://ncbi.nlm.nih.gov/pubmed/27501182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2016-1272
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