Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity

Thyroid hormone binds to nuclear receptors and regulates gene transcription. Here we report that in mice, at around the first day of life, there is a transient surge in hepatocyte type 2 deiodinase (D2) that activates the prohormone thyroxine to the active hormone triiodothyronine, modifying the exp...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Fonseca, Tatiana L., Fernandes, Gustavo W., McAninch, Elizabeth A., Bocco, Barbara M. L. C., Abdalla, Sherine M., Ribeiro, Miriam O., Mohácsik, Petra, Fekete, Csaba, Li, Daofeng, Xing, Xiaoyun, Wang, Ting, Gereben, Balázs, Bianco, Antonio C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2015
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653175/
https://ncbi.nlm.nih.gov/pubmed/26508642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1508943112
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