Endoplasmic Reticulum Stress Decreases Intracellular Thyroid Hormone Activation via an eIF2a-Mediated Decrease in Type 2 Deiodinase Synthesis

Cells respond rapidly to endoplasmic reticulum (ER) stress by blocking protein translation, increasing protein folding capacity, and accelerating degradation of unfolded proteins via ubiquitination and ER-associated degradation pathways. The ER resident type 2 deiodinase (D2) is normally ubiquitinat...

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Detalhes bibliográficos
Main Authors: Arrojo e Drigo, Rafael, Fonseca, Tatiana L., Castillo, Melany, Salathe, Matthias, Simovic, Gordana, Mohácsik, Petra, Gereben, Balazs, Bianco, Antonio C.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2011
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3231828/
https://ncbi.nlm.nih.gov/pubmed/22053000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2011-1061
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