Differences in hypothalamic type 2 deiodinase ubiquitination explain localized sensitivity to thyroxine

The current treatment for patients with hypothyroidism is levothyroxine (L-T4) along with normalization of serum thyroid-stimulating hormone (TSH). However, normalization of serum TSH with L-T4 monotherapy results in relatively low serum 3,5,3′-triiodothyronine (T3) and high serum thyroxine/T3 (T4/T...

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發表在:J Clin Invest
Main Authors: Werneck de Castro, Joao Pedro, Fonseca, Tatiana L., Ueta, Cintia B., McAninch, Elizabeth A., Abdalla, Sherine, Wittmann, Gabor, Lechan, Ronald M., Gereben, Balazs, Bianco, Antonio C.
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2015
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319436/
https://ncbi.nlm.nih.gov/pubmed/25555216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI77588
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