Type 2 deiodinase polymorphism causes ER stress and hypothyroidism in the brain

Levothyroxine (LT4) is a form of thyroid hormone used to treat hypothyroidism. In the brain, T4 is converted to the active form T3 by type 2 deiodinase (D2). Thus, it is intriguing that carriers of the Thr92Ala polymorphism in the D2 gene (DIO2) exhibit clinical improvement when liothyronine (LT3) i...

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Vydáno v:J Clin Invest
Hlavní autoři: Jo, Sungro, Fonseca, Tatiana L., Bocco, Barbara M. L. C., Fernandes, Gustavo W., McAninch, Elizabeth A., Bolin, Anaysa P., Da Conceição, Rodrigo R., Werneck-de-Castro, Joao Pedro, Ignacio, Daniele L., Egri, Péter, Németh, Dorottya, Fekete, Csaba, Bernardi, Maria Martha, Leitch, Victoria D., Mannan, Naila S., Curry, Katharine F., Butterfield, Natalie C., Bassett, J.H. Duncan, Williams, Graham R., Gereben, Balázs, Ribeiro, Miriam O., Bianco, Antonio C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6307951/
https://ncbi.nlm.nih.gov/pubmed/30352046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI123176
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