TNF/TNFR axis promotes pyrin inflammasome activation and distinctly modulates pyrin inflammasomopathy

Pyrin is an inflammasome sensor that promotes caspase-1–mediated pyroptotic cell death and maturation of proinflammatory cytokines IL-1β and IL-18. Familial Mediterranean fever (FMF), an autoinflammatory disorder, is associated with mutations in the gene encoding pyrin (MEFV). FMF-knockin (FMF-KI) m...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: Sharma, Deepika, Malik, Ankit, Guy, Clifford, Vogel, Peter, Kanneganti, Thirumala-Devi
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6307946/
https://ncbi.nlm.nih.gov/pubmed/30457980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI121372
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