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Plasma and cerebrospinal fluid pharmacokinetics of the Akt inhibitor, perifosine, in a non‑human primate model

PURPOSE: Central nervous system tumors are histologically and biologically heterogeneous. Standard treatment for malignant tumors includes surgery, radiation and chemotherapy, yet surgical resection is not always an option and chemotherapeutic agents have limited benefit. Recent investigations have...

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Vydáno v:Cancer Chemother Pharmacol
Hlavní autoři: Cole, Diane E., Lester-McCully, Cynthia M., Widemann, Brigitte C., Warren, Katherine E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6301001/
https://ncbi.nlm.nih.gov/pubmed/25740692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-015-2711-1
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