Loading...

Plasma and cerebrospinal fluid pharmacokinetics of the DNA methyltransferase inhibitor, 5-azacytidine, alone and with inulin, in nonhuman primate models

BACKGROUND: Epigenetic modifiers are being investigated for a number of CNS malignancies as tumor-associated mutations such as isocitrate dehydrogenase mutations (IDH1/IDH2) and H3K27M mutations, which result in aberrant signaling, are identified. We evaluated the CNS exposure of the DNA methyltrans...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Neurooncol Adv
Main Authors: Lester McCully, Cynthia, Rodgers, Louis T, Cruz, Rafael, Thomas, Marvin L, Peer, Cody J, Figg, William D, Warren, Katherine E
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7146732/
https://ncbi.nlm.nih.gov/pubmed/32309806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdaa005
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!