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Plasma and cerebrospinal fluid pharmacokinetics of the DNA methyltransferase inhibitor, 5-azacytidine, alone and with inulin, in nonhuman primate models

BACKGROUND: Epigenetic modifiers are being investigated for a number of CNS malignancies as tumor-associated mutations such as isocitrate dehydrogenase mutations (IDH1/IDH2) and H3K27M mutations, which result in aberrant signaling, are identified. We evaluated the CNS exposure of the DNA methyltrans...

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書誌詳細
出版年:Neurooncol Adv
主要な著者: Lester McCully, Cynthia, Rodgers, Louis T, Cruz, Rafael, Thomas, Marvin L, Peer, Cody J, Figg, William D, Warren, Katherine E
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7146732/
https://ncbi.nlm.nih.gov/pubmed/32309806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdaa005
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