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Flow Rate and Apparent Volume of Cerebrospinal Fluid in Rhesus Macaques (Macaca mulatta) Based on the Pharmacokinetics of Intrathecally Administered Inulin

Cerebrospinal fluid (CSF) flow rate and volume are fundamental to the design and interpretation of preclinical pharmacokinetics and pharmacodynamics studies in NHP. To determine the values of CSF flow rate and volume, we evaluated the plasma and CSF pharmacokinetics of inulin, an inert polysaccharid...

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書誌詳細
出版年:Comp Med
主要な著者: McCully, Cynthia M Lester, Rodgers, Louis T, Garica, Rafael Cruz, III, Marvin L Thomas, Peer, Cody J, Figg, William D, Barnard, Dennis E, Warren, Katherine E
フォーマット: Artigo
言語:Inglês
出版事項: American Association for Laboratory Animal Science 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7754203/
https://ncbi.nlm.nih.gov/pubmed/33046181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.30802/AALAS-CM-99-990010
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