Flow Rate and Apparent Volume of Cerebrospinal Fluid in Rhesus Macaques (Macaca mulatta) Based on the Pharmacokinetics of Intrathecally Administered Inulin

Cerebrospinal fluid (CSF) flow rate and volume are fundamental to the design and interpretation of preclinical pharmacokinetics and pharmacodynamics studies in NHP. To determine the values of CSF flow rate and volume, we evaluated the plasma and CSF pharmacokinetics of inulin, an inert polysaccharid...

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Bibliographische Detailangaben
Veröffentlicht in:Comp Med
Hauptverfasser: McCully, Cynthia M Lester, Rodgers, Louis T, Garica, Rafael Cruz, III, Marvin L Thomas, Peer, Cody J, Figg, William D, Barnard, Dennis E, Warren, Katherine E
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for Laboratory Animal Science 2020
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7754203/
https://ncbi.nlm.nih.gov/pubmed/33046181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.30802/AALAS-CM-99-990010
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