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EXTH-02. PLASMA AND CEREBROSPINAL FLUID PHARMACOKINETICS OF 5-AZACYTIDINE ALONE AND IN COMBINATION WITH INULIN IN A NON-HUMAN PRIMATE MODEL
BACKGROUND: To evaluate the CNS exposure of 5-azacytidine (5-AZA) plasma and CSF pharmacokinetics (PK) and cortical extracellular fluid (ECF) concentrations, via microdialysis (MD), were studied in a nonhuman primate model (NHP) following intravenous (IV), intranasal (IN), intraventricular (IT-V), i...
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| Publicado no: | Neuro Oncol |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5693156/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.298 |
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