EXTH-65. PLASMA AND CEREBROSPINAL FLUID PHARMACOKINETICS COMPARISON OF BRAF AND MEK INHIBITORS FOLLOWING SINGLE AND EXTENDED ADMINISTRATION IN A PRE-CLINICAL NON-HUMAN PRIMATE MODEL

BACKGROUND: Aberrations in the MAPK signaling pathway are present in adult and pediatric CNS tumors. The BRAF and MEK inhibitors Dabrafenib, Vemurafenib, Selumetinib and Trametinib, alone or in combination, have demonstrated clinical efficacy. However, minimal CSF penetration has been demonstrated i...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Lester McCully, Cynthia, Gross, Andrea, Cruz Garcia, Rafael, Shankarappa, Priya, Odabas, Arman, Rodgers, Louis, Peer, Cody, Figg, William, Widemann, Brigitte, Warren, Katherine
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6846912/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.395
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