TRTH-33. COMPARATIVE PLASMA AND CEREBROSPINAL FLUID PHARMACOKINETICS OF BRAF AND MEK INHIBITORS IN A NONHUMAN PRIMATE MODEL

PURPOSE: BRAF(V600E) mutations are present in several pediatric CNS tumors, particularly pilocytic astrocytomas, gangliogliomas and pleomorphic xanthochromic astrocytomas. Several BRAF inhibitors are under clinical investigation, alone and in combination with MEK inhibitors. To guide the clinical de...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Neuro Oncol
Autores principales: Rodgers, Louis, M Lester McCully, Cynthia, Gross, Andrea, Peer, Cody, Cruz, Rafael, Figg, William D, Widemann, Brigette, Warren, Katherine
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2017
Materias:
Abstracts
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5475218/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox083.243
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares