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TRTH-33. COMPARATIVE PLASMA AND CEREBROSPINAL FLUID PHARMACOKINETICS OF BRAF AND MEK INHIBITORS IN A NONHUMAN PRIMATE MODEL
PURPOSE: BRAF(V600E) mutations are present in several pediatric CNS tumors, particularly pilocytic astrocytomas, gangliogliomas and pleomorphic xanthochromic astrocytomas. Several BRAF inhibitors are under clinical investigation, alone and in combination with MEK inhibitors. To guide the clinical de...
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| Gepubliceerd in: | Neuro Oncol |
|---|---|
| Hoofdauteurs: | , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Oxford University Press
2017
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5475218/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox083.243 |
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