TRTH-33. COMPARATIVE PLASMA AND CEREBROSPINAL FLUID PHARMACOKINETICS OF BRAF AND MEK INHIBITORS IN A NONHUMAN PRIMATE MODEL

PURPOSE: BRAF(V600E) mutations are present in several pediatric CNS tumors, particularly pilocytic astrocytomas, gangliogliomas and pleomorphic xanthochromic astrocytomas. Several BRAF inhibitors are under clinical investigation, alone and in combination with MEK inhibitors. To guide the clinical de...

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Publicado en:Neuro Oncol
Main Authors: Rodgers, Louis, M Lester McCully, Cynthia, Gross, Andrea, Peer, Cody, Cruz, Rafael, Figg, William D, Widemann, Brigette, Warren, Katherine
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5475218/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox083.243
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