EXTH-02. PLASMA AND CEREBROSPINAL FLUID PHARMACOKINETICS OF 5-AZACYTIDINE ALONE AND IN COMBINATION WITH INULIN IN A NON-HUMAN PRIMATE MODEL

BACKGROUND: To evaluate the CNS exposure of 5-azacytidine (5-AZA) plasma and CSF pharmacokinetics (PK) and cortical extracellular fluid (ECF) concentrations, via microdialysis (MD), were studied in a nonhuman primate model (NHP) following intravenous (IV), intranasal (IN), intraventricular (IT-V), i...

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Published in:Neuro Oncol
Main Authors: McCully, Cynthia Lester, Rodgers, Louis, Cruz, Rafael, Thomas, Marvin, Peer, Cody, Figg, William D, Warren, Katherine E
Format: Artigo
Language:Inglês
Published: Oxford University Press 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5693156/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.298
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