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The plasma and cerebrospinal fluid pharmacokinetics of sorafenib after intravenous administration in non-human primates
Purpose Sorafenib is a small molecule inhibitor of multiple signaling kinases thought to contribute to the pathogenesis of many tumors including brain tumors. Clinical trials with sorafenib in primary and metastatic brain tumors are ongoing. We evaluated the plasma and cerebrospinal fluid (CSF) phar...
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| Pubblicato in: | Invest New Drugs |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6636925/ https://ncbi.nlm.nih.gov/pubmed/21072558 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-010-9585-1 |
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