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The plasma and cerebrospinal fluid pharmacokinetics of sorafenib after intravenous administration in non-human primates

Purpose Sorafenib is a small molecule inhibitor of multiple signaling kinases thought to contribute to the pathogenesis of many tumors including brain tumors. Clinical trials with sorafenib in primary and metastatic brain tumors are ongoing. We evaluated the plasma and cerebrospinal fluid (CSF) phar...

詳細記述

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書誌詳細
出版年:Invest New Drugs
主要な著者: Kim, AeRang, McCully, Cindy, Cruz, Rafael, Cole, Diane E., Fox, Elizabeth, Balis, Frank M., Widemann, Brigitte C.
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6636925/
https://ncbi.nlm.nih.gov/pubmed/21072558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-010-9585-1
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