The plasma and cerebrospinal fluid pharmacokinetics of the platinum analog satraplatin after intravenous administration in non-human primates

BACKGROUND: Satraplatin is an orally bioavailable platinum analog with preclinical activity in cisplatin resistant models and clinical activity in adults with refractory cancers. The cerebrospinal fluid (CSF) penetration of cisplatin and carboplatin in non-human primates (NHP) is limited (3.7 and 2....

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Detalhes bibliográficos
Publicado no:Cancer Chemother Pharmacol
Main Authors: Marcus, Leigh, Murphy, Robert, Fox, Elizabeth, McCully, Cynthia, Cruz, Raphael, Warren, Katherine E., Meyer, Thorsten, McNiff, Edward, Balis, Frank M., Widemann, Brigitte C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6300136/
https://ncbi.nlm.nih.gov/pubmed/21706317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-011-1659-z
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