CRISPR-C: circularization of genes and chromosome by CRISPR in human cells

Extrachromosomal circular DNA (eccDNA) and ring chromosomes are genetic alterations found in humans with genetic disorders. However, there is a lack of genetic engineering tools to recapitulate and study the biogenesis of eccDNAs. Here, we created a dual-fluorescence biosensor cassette, which upon t...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Møller, Henrik Devitt, Lin, Lin, Xiang, Xi, Petersen, Trine Skov, Huang, Jinrong, Yang, Luhan, Kjeldsen, Eigil, Jensen, Uffe Birk, Zhang, Xiuqing, Liu, Xin, Xu, Xun, Wang, Jian, Yang, Huanming, Church, George M, Bolund, Lars, Regenberg, Birgitte, Luo, Yonglun
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Methods Online
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6294522/
https://ncbi.nlm.nih.gov/pubmed/30551175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky767
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