Haplotyping by CRISPR-mediated DNA circularization (CRISPR-hapC) broadens allele-specific gene editing

Allele-specific protospacer adjacent motif (asPAM)-positioning SNPs and CRISPRs are valuable resources for gene therapy of dominant disorders. However, one technical hurdle is to identify the haplotype comprising the disease-causing allele and the distal asPAM SNPs. Here, we describe a novel CRISPR-...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Nucleic Acids Res
Päätekijät: Yu, Jiaying, Xiang, Xi, Huang, Jinrong, Liang, Xue, Pan, Xiaoguang, Dong, Zhanying, Petersen, Trine Skov, Qu, Kunli, Yang, Ling, Zhao, Xiaoying, Li, Siyuan, Zheng, Tianyu, Xu, Zhe, Liu, Chengxun, Han, Peng, Xu, Fengping, Yang, Huanming, Liu, Xin, Zhang, Xiuqing, Bolund, Lars, Luo, Yonglun, Lin, Lin
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2020
Aiheet:
Methods Online
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7049710/
https://ncbi.nlm.nih.gov/pubmed/31943080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz1233
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