Chemical genetic identification of CDKL5 substrates reveals its role in neuronal microtubule dynamics

Loss‐of‐function mutations in CDKL5 kinase cause severe neurodevelopmental delay and early‐onset seizures. Identification of CDKL5 substrates is key to understanding its function. Using chemical genetics, we found that CDKL5 phosphorylates three microtubule‐associated proteins: MAP1S, EB2 and ARHGEF...

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Publicat a:EMBO J
Autors principals: Baltussen, Lucas L, Negraes, Priscilla D, Silvestre, Margaux, Claxton, Suzanne, Moeskops, Max, Christodoulou, Evangelos, Flynn, Helen R, Snijders, Ambrosius P, Muotri, Alysson R, Ultanir, Sila K
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2018
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6293278/
https://ncbi.nlm.nih.gov/pubmed/30266824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201899763
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