Chemical genetic identification of CDKL5 substrates reveals its role in neuronal microtubule dynamics

Loss‐of‐function mutations in CDKL5 kinase cause severe neurodevelopmental delay and early‐onset seizures. Identification of CDKL5 substrates is key to understanding its function. Using chemical genetics, we found that CDKL5 phosphorylates three microtubule‐associated proteins: MAP1S, EB2 and ARHGEF...

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Bibliographic Details
Published in:EMBO J
Main Authors: Baltussen, Lucas L, Negraes, Priscilla D, Silvestre, Margaux, Claxton, Suzanne, Moeskops, Max, Christodoulou, Evangelos, Flynn, Helen R, Snijders, Ambrosius P, Muotri, Alysson R, Ultanir, Sila K
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6293278/
https://ncbi.nlm.nih.gov/pubmed/30266824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201899763
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