Molecular basis for substrate specificity of the Phactr1/PP1 phosphatase holoenzyme

PPP-family phosphatases such as PP1 have little intrinsic specificity. Cofactors can target PP1 to substrates or subcellular locations, but it remains unclear how they might confer sequence-specificity on PP1. The cytoskeletal regulator Phactr1 is a neuronally enriched PP1 cofactor that is controlle...

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Vydáno v:eLife
Hlavní autoři: Fedoryshchak, Roman O, Přechová, Magdalena, Butler, Abbey M, Lee, Rebecca, O'Reilly, Nicola, Flynn, Helen R, Snijders, Ambrosius P, Eder, Noreen, Ultanir, Sila, Mouilleron, Stephane, Treisman, Richard
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2020
Témata:
Biochemistry and Chemical Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7599070/
https://ncbi.nlm.nih.gov/pubmed/32975518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.61509
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