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Molecular basis for substrate specificity of the Phactr1/PP1 phosphatase holoenzyme
PPP-family phosphatases such as PP1 have little intrinsic specificity. Cofactors can target PP1 to substrates or subcellular locations, but it remains unclear how they might confer sequence-specificity on PP1. The cytoskeletal regulator Phactr1 is a neuronally enriched PP1 cofactor that is controlle...
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| Pubblicato in: | eLife |
|---|---|
| Autori principali: | , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
eLife Sciences Publications, Ltd
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7599070/ https://ncbi.nlm.nih.gov/pubmed/32975518 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.61509 |
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