Chemical genetic identification of GAK substrates reveals its role in regulating Na(+)/K(+)-ATPase

Cyclin G–associated kinase (GAK) is a ubiquitous serine/threonine kinase that facilitates clathrin uncoating during vesicle trafficking. GAK phosphorylates a coat adaptor component, AP2M1, to help achieve this function. GAK is also implicated in Parkinson's disease through genome-wide associati...

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Udgivet i:Life Sci Alliance
Main Authors: Lin, Amy W, Gill, Kalbinder K, Castañeda, Marisol Sampedro, Matucci, Irene, Eder, Noreen, Claxton, Suzanne, Flynn, Helen, Snijders, Ambrosius P, George, Roger, Ultanir, Sila K
Format: Artigo
Sprog:Inglês
Udgivet: Life Science Alliance LLC 2018
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6312924/
https://ncbi.nlm.nih.gov/pubmed/30623173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201800118
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