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YAP1/TAZ drives ependymoma-like tumour formation in mice
YAP1 gene fusions have been observed in a subset of paediatric ependymomas. Here we show that, ectopic expression of active nuclear YAP1 (nlsYAP5SA) in ventricular zone neural progenitor cells using conditionally-induced NEX/NeuroD6-Cre is sufficient to drive brain tumour formation in mice. Neuronal...
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| Udgivet i: | Nat Commun |
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| Main Authors: | , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7220953/ https://ncbi.nlm.nih.gov/pubmed/32404936 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16167-y |
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