YAP1/TAZ drives ependymoma-like tumour formation in mice

YAP1 gene fusions have been observed in a subset of paediatric ependymomas. Here we show that, ectopic expression of active nuclear YAP1 (nlsYAP5SA) in ventricular zone neural progenitor cells using conditionally-induced NEX/NeuroD6-Cre is sufficient to drive brain tumour formation in mice. Neuronal...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:Nat Commun
Hoofdauteurs: Eder, Noreen, Roncaroli, Federico, Dolmart, Marie-Charlotte, Horswell, Stuart, Andreiuolo, Felipe, Flynn, Helen R., Lopes, Andre T., Claxton, Suzanne, Kilday, John-Paul, Collinson, Lucy, Mao, Jun-Hao, Pietsch, Torsten, Thompson, Barry, Snijders, Ambrosius P., Ultanir, Sila K.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2020
Onderwerpen:
Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7220953/
https://ncbi.nlm.nih.gov/pubmed/32404936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16167-y
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items