YAP1/TAZ drives ependymoma-like tumour formation in mice

YAP1 gene fusions have been observed in a subset of paediatric ependymomas. Here we show that, ectopic expression of active nuclear YAP1 (nlsYAP5SA) in ventricular zone neural progenitor cells using conditionally-induced NEX/NeuroD6-Cre is sufficient to drive brain tumour formation in mice. Neuronal...

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Udgivet i:Nat Commun
Main Authors: Eder, Noreen, Roncaroli, Federico, Dolmart, Marie-Charlotte, Horswell, Stuart, Andreiuolo, Felipe, Flynn, Helen R., Lopes, Andre T., Claxton, Suzanne, Kilday, John-Paul, Collinson, Lucy, Mao, Jun-Hao, Pietsch, Torsten, Thompson, Barry, Snijders, Ambrosius P., Ultanir, Sila K.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7220953/
https://ncbi.nlm.nih.gov/pubmed/32404936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16167-y
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