Chemical genetic identification of CDKL5 substrates reveals its role in neuronal microtubule dynamics

Loss‐of‐function mutations in CDKL5 kinase cause severe neurodevelopmental delay and early‐onset seizures. Identification of CDKL5 substrates is key to understanding its function. Using chemical genetics, we found that CDKL5 phosphorylates three microtubule‐associated proteins: MAP1S, EB2 and ARHGEF...

詳細記述

保存先:
書誌詳細
出版年:EMBO J
主要な著者: Baltussen, Lucas L, Negraes, Priscilla D, Silvestre, Margaux, Claxton, Suzanne, Moeskops, Max, Christodoulou, Evangelos, Flynn, Helen R, Snijders, Ambrosius P, Muotri, Alysson R, Ultanir, Sila K
フォーマット: Artigo
言語:Inglês
出版事項: John Wiley and Sons Inc. 2018
主題:
Articles
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6293278/
https://ncbi.nlm.nih.gov/pubmed/30266824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201899763
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