Role of the C‐terminus of SUR in the differential regulation of β‐cell and cardiac K(ATP) channels by MgADP and metabolism

KEY POINTS: β‐Cell K(ATP) channels are partially open in the absence of metabolic substrates, whereas cardiac K(ATP) channels are closed. Using cloned channels heterologously expressed in Xenopus oocytes we measured the effect of MgADP on the MgATP concentration–inhibition curve immediately after pa...

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Bibliographic Details
Published in:J Physiol
Main Authors: Vedovato, Natascia, Rorsman, Olof, Hennis, Konstantin, Ashcroft, Frances M., Proks, Peter
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2018
Subjects:
Molecular and cellular
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6292810/
https://ncbi.nlm.nih.gov/pubmed/30179258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP276708
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