Carbamazepine inhibits ATP-sensitive potassium channel activity by disrupting channel response to MgADP

In pancreatic β-cells, K(ATP) channels consisting of Kir6.2 and SUR1 couple cell metabolism to membrane excitability and regulate insulin secretion. Sulfonylureas, insulin secretagogues used to treat type II diabetes, inhibit K(ATP) channel activity primarily by abolishing the stimulatory effect of...

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Main Authors: Zhou, Qing, Chen, Pei-Chun, Devaraneni, Prasanna K, Martin, Gregory M, Olson, Erik M, Shyng, Show-Ling
格式: Artigo
語言:Inglês
出版: Landes Bioscience 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4203739/
https://ncbi.nlm.nih.gov/pubmed/24849284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/chan.29117
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