Carbamazepine inhibits ATP-sensitive potassium channel activity by disrupting channel response to MgADP

In pancreatic β-cells, K(ATP) channels consisting of Kir6.2 and SUR1 couple cell metabolism to membrane excitability and regulate insulin secretion. Sulfonylureas, insulin secretagogues used to treat type II diabetes, inhibit K(ATP) channel activity primarily by abolishing the stimulatory effect of...

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Hlavní autoři: Zhou, Qing, Chen, Pei-Chun, Devaraneni, Prasanna K, Martin, Gregory M, Olson, Erik M, Shyng, Show-Ling
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2014
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Article Addendum
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4203739/
https://ncbi.nlm.nih.gov/pubmed/24849284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/chan.29117
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