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Carbamazepine inhibits ATP-sensitive potassium channel activity by disrupting channel response to MgADP
In pancreatic β-cells, K(ATP) channels consisting of Kir6.2 and SUR1 couple cell metabolism to membrane excitability and regulate insulin secretion. Sulfonylureas, insulin secretagogues used to treat type II diabetes, inhibit K(ATP) channel activity primarily by abolishing the stimulatory effect of...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Landes Bioscience
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4203739/ https://ncbi.nlm.nih.gov/pubmed/24849284 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/chan.29117 |
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