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Role of the C‐terminus of SUR in the differential regulation of β‐cell and cardiac K(ATP) channels by MgADP and metabolism

KEY POINTS: β‐Cell K(ATP) channels are partially open in the absence of metabolic substrates, whereas cardiac K(ATP) channels are closed. Using cloned channels heterologously expressed in Xenopus oocytes we measured the effect of MgADP on the MgATP concentration–inhibition curve immediately after pa...

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發表在:J Physiol
Main Authors: Vedovato, Natascia, Rorsman, Olof, Hennis, Konstantin, Ashcroft, Frances M., Proks, Peter
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6292810/
https://ncbi.nlm.nih.gov/pubmed/30179258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP276708
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