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Evidence of disulfide bond scrambling during production of an antibody-drug conjugate
Antibody-drug conjugates (ADCs) that are formed using thiol-maleimide chemistry are commonly produced by reactions that occur at or above neutral pHs. Alkaline environments can promote disulfide bond scrambling, and may result in the reconfiguration of interchain disulfide bonds in IgG antibodies, p...
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| 出版年: | MAbs |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Taylor & Francis
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6284598/ https://ncbi.nlm.nih.gov/pubmed/30339473 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2018.1521128 |
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