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Evidence of disulfide bond scrambling during production of an antibody-drug conjugate
Antibody-drug conjugates (ADCs) that are formed using thiol-maleimide chemistry are commonly produced by reactions that occur at or above neutral pHs. Alkaline environments can promote disulfide bond scrambling, and may result in the reconfiguration of interchain disulfide bonds in IgG antibodies, p...
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| Publicado no: | MAbs |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6284598/ https://ncbi.nlm.nih.gov/pubmed/30339473 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2018.1521128 |
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