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Evidence of disulfide bond scrambling during production of an antibody-drug conjugate

Antibody-drug conjugates (ADCs) that are formed using thiol-maleimide chemistry are commonly produced by reactions that occur at or above neutral pHs. Alkaline environments can promote disulfide bond scrambling, and may result in the reconfiguration of interchain disulfide bonds in IgG antibodies, p...

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Pubblicato in:MAbs
Autori principali: Liu-Shin, Lily Pei-Yao, Fung, Adam, Malhotra, Arun, Ratnaswamy, Gayathri
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284598/
https://ncbi.nlm.nih.gov/pubmed/30339473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2018.1521128
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