Evidence of disulfide bond scrambling during production of an antibody-drug conjugate

Antibody-drug conjugates (ADCs) that are formed using thiol-maleimide chemistry are commonly produced by reactions that occur at or above neutral pHs. Alkaline environments can promote disulfide bond scrambling, and may result in the reconfiguration of interchain disulfide bonds in IgG antibodies, p...

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Bibliographic Details
Published in:MAbs
Main Authors: Liu-Shin, Lily Pei-Yao, Fung, Adam, Malhotra, Arun, Ratnaswamy, Gayathri
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284598/
https://ncbi.nlm.nih.gov/pubmed/30339473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2018.1521128
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